A brief history of the fall of Rome

The dissolution of the Western Roman Empire is popularly perceived as a sudden and dramatic cataclysm, with the “fall of Rome” often precisely dated to 476 CE. In that year, so the story goes, the child Emperor of the West (later derisively referred to as Romulus Augustulus), was deposed by the barbarian warlord Odoacer who…

Hypoxia, anoxia, lactic acid fermentation, and naked mole rats…

Fermentation is the ancient and evolutionarily conserved metabolic process by which glycolytic pyruvate is reduced by the electron carrier NADH, thus regenerating NAD+ while producing any of a number organism-specific end products. For example in yeast, the fermentation end product is ethanol, while in mammals, the end product is lactate. In mammals, this process occurs…